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Title:

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling.

Document type:
Journal Article
Author(s):
Lopez, Melina; Malacarne, Pedro F; Ramanujam, Deepak P; Warwick, Timothy; Müller, Niklas; Hu, Jiong; Dewenter, Matthias; Weigert, Andreas; Günther, Stefan; Gilsbach, Ralf; Engelhardt, Stefan; Brandes, Ralf P; Rezende, Flávia
Abstract:
The cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular system, the POR/CYP450 system has been linked to the production of epoxyeicosatrienoic acids (EETs) but also to the generation of reactive oxygen species. In cardiac myocytes (CMs), EETs have been shown to modulate the cardiac function and have cardioprotective effects. The functional importance of the endothelial POR/CYP450 system in the hear...     »
Journal title abbreviation:
Front Physiol
Year:
2022
Journal volume:
13
Fulltext / DOI:
doi:10.3389/fphys.2022.1056369
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36531184
Print-ISSN:
1664-042X
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX