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Titel:

From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo.

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Andergassen, Daniel; Rinn, John L
Abstract:
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA (lncRNA) loci in the human genome, but evidence of functional significance has remained controversial for many lncRNAs. Genetically engineered model organisms are considered the gold standard for linking genotype to phenotype. Recent advances in CRISPR-Cas genome editing have led to a rapid increase in the use of mouse models to more readily survey lncRNAs for functional significance. Here, we review strategies t...     »
Zeitschriftentitel:
Nat Rev Genet
Jahr:
2022
Band / Volume:
23
Heft / Issue:
4
Seitenangaben Beitrag:
229-243
Volltext / DOI:
doi:10.1038/s41576-021-00427-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34837040
Print-ISSN:
1471-0056
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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