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Titel:

MicroRNA-365 regulates human cardiac action potential duration.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Esfandyari, Dena; Idrissou, Bio Maria Ghéo; Hennis, Konstantin; Avramopoulos, Petros; Dueck, Anne; El-Battrawy, Ibrahim; Grüter, Laurenz; Meier, Melanie Annemarie; Näger, Anna Christina; Ramanujam, Deepak; Dorn, Tatjana; Meitinger, Thomas; Hagl, Christian; Milting, Hendrik; Borggrefe, Martin; Fenske, Stefanie; Biel, Martin; Dendorfer, Andreas; Sassi, Yassine; Moretti, Alessandra; Engelhardt, Stefan
Abstract:
Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and sudden cardiac death. Here, we aim to identify microRNAs that regulate the human cardiac action potential and ask whether their manipulation allows for therapeutic modulation of action potential abnormalities. Quantitative analysis of the microRNA targetomes in human cardiac myocytes identifies miR-365 as a primary microRNA to regulate repolarizing ion channels. Action potential recordings in patient-specific i...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2022
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-021-27856-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35017523
Print-ISSN:
2041-1723
TUM Einrichtung:
592; 594; Institut für Humangenetik; Institut für Pharmakologie und Toxikologie; Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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