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Title:

Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Tran, Tiffany M; Sherwood, Jessica K; Doolittle, Michael J; Sathler, Matheus F; Hofmann, Franz; Stone-Roy, Leslie M; Kim, Seonil
Abstract:
Chromosome 4q21 microdeletion leads to a human syndrome that exhibits restricted growth, facial dysmorphisms, mental retardation, and absent or delayed speech. One of the key genes in the affected region of the chromosome is PRKG2, which encodes cGMP-dependent protein kinase II (cGKII). Mice lacking cGKII exhibit restricted growth and deficits in learning and memory, as seen in the human syndrome. However, vocalization impairments in these mice have not been determined. The molecular pathway und...     »
Journal title abbreviation:
Neurosci Lett
Year:
2021
Journal volume:
759
Fulltext / DOI:
doi:10.1016/j.neulet.2021.136048
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34126178
Print-ISSN:
0304-3940
TUM Institution:
Institut für Pharmakologie und Toxikologie
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