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Title:

The emerging landscape of single-molecule protein sequencing technologies

Document type:
Zeitschriftenaufsatz
Author(s):
Alfaro, Javier Antonio; Bohländer, Peggy; Dai, Mingjie; Filius, Mike; Howard, Cecil J.; van Kooten, Xander F.; Ohayon, Shilo; Pomorski, Adam; Schmid, Sonja; Aksimentiev, Aleksei; Anslyn, Eric V.; Bedran, Georges; Cao, Chan; Chinappi, Mauro; Coyaud, Etienne; Dekker, Cees; Dittmar, Gunnar; Drachman, Nicholas; Eelkema, Rienk; Goodlett, David; Hentz, Sébastien; Kalathiya, Umesh; Kelleher, Neil L.; Kelly, Ryan T.; Kelman, Zvi; Kim, Sung Hyun; Kuster, Bernhard; Rodriguez-Larrea, David; Lindsay, Stuart...     »
Abstract:
Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biologica...     »
Journal title:
Nature Methods
Year:
2021
Journal volume:
18
Journal issue:
6
Pages contribution:
604-617
Fulltext / DOI:
doi:10.1038/s41592-021-01143-1
Publisher:
Springer Science and Business Media LLC
E-ISSN:
1548-70911548-7105
Date of publication:
01.06.2021
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