User: Guest  Login
Title:

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Sadras, Teresa; Martin, Mickaël; Kume, Kohei; Robinson, Mark E; Saravanakumar, Supraja; Lenz, Gal; Chen, Zhengshan; Song, Joo Y; Siddiqi, Tanya; Oksa, Laura; Knapp, Anne Marie; Cutler, Jevon; Cosgun, Kadriye Nehir; Klemm, Lars; Ecker, Veronika; Winchester, Janet; Ghergus, Dana; Soulas-Sprauel, Pauline; Kiefer, Friedemann; Heisterkamp, Nora; Pandey, Akhilesh; Ngo, Vu; Wang, Lili; Jumaa, Hassan; Buchner, Maike; Ruland, Jürgen; Chan, Wing-Chung; Meffre, Eric; Martin, Thierry; Müschen, Markus
Abstract:
Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B and T cells is strictly segregated throughout evolution. Here, we identified aberrant ZAP70 expression as a common feature in a broad range of B cell malignancies. We validated SYK as the kinase that sets the thresholds for negative selection of autoreactive and premalignant clones. When aberrantly expressed in B cells, ZAP70 competes with SYK at the BCR signalosome and redirects S...     »
Journal title abbreviation:
Mol Cell
Year:
2021
Journal volume:
81
Journal issue:
10
Pages contribution:
2094-2111.e9
Fulltext / DOI:
doi:10.1016/j.molcel.2021.03.043
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33878293
Print-ISSN:
1097-2765
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
 BibTeX