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Title:

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ramanujam, Deepak; Schön, Anna Patricia; Beck, Christina; Vaccarello, Paula; Felician, Giulia; Dueck, Anne; Esfandyari, Dena; Meister, Gunter; Meitinger, Thomas; Schulz, Christian; Engelhardt, Stefan
Abstract:
BACKGROUND: Cardiac macrophages (cMPs) are increasingly recognized as important regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these cells is largely unknown. Small RNA sequencing of the entire miRNomes of the major cardiac cell fractions revealed microRNA-21 (miR-21) as the single highest expressed microRNA in cMPs, both in health and disease (25% and 43% of all microRNA reads, respectively). MiR-21 has been previously reported as a key microRNA driving tissu...     »
Journal title abbreviation:
Circulation
Year:
2021
Journal volume:
143
Journal issue:
15
Pages contribution:
1513-1525
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.050682
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33550817
Print-ISSN:
0009-7322
TUM Institution:
Institut für Humangenetik; Institut für Pharmakologie und Toxikologie
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