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- Title:
IFN-1s: Sentinels Shaping Distinct Immune Responses in Skin.
- Document type:
- Journal Article; Comment
- Author(s):
- Garzorz-Stark, Natalie; Eyerich, Kilian
- Abstract:
- IFN-1s are early sentinels of potential danger in skin. Two interconnected axes exist: plasmacytoid dendritic cells (DCs) secreting IFN-α in response to single strand RNA or DNA and keratinocytes secreting IFN-κ after stimulation with double strand RNA or other IFNs. Both IFN-α and IFN-κ induce macrophages and DC subpopulations to secrete master regulators of cytotoxicity or wound healing, the latter related to psoriasis pathogenesis.
- Journal title abbreviation:
- J Invest Dermatol
- Year:
- 2022
- Journal volume:
- 142
- Journal issue:
- 1
- Pages contribution:
- 14-15
- Fulltext / DOI:
- doi:10.1016/j.jid.2021.07.161
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/34565563
- Print-ISSN:
- 0022-202X
- TUM Institution:
- Klinik und Poliklinik für Dermatologie und Allergologie
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