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Title:

IFN-1s: Sentinels Shaping Distinct Immune Responses in Skin.

Document type:
Journal Article; Comment
Author(s):
Garzorz-Stark, Natalie; Eyerich, Kilian
Abstract:
IFN-1s are early sentinels of potential danger in skin. Two interconnected axes exist: plasmacytoid dendritic cells (DCs) secreting IFN-α in response to single strand RNA or DNA and keratinocytes secreting IFN-κ after stimulation with double strand RNA or other IFNs. Both IFN-α and IFN-κ induce macrophages and DC subpopulations to secrete master regulators of cytotoxicity or wound healing, the latter related to psoriasis pathogenesis.
Journal title abbreviation:
J Invest Dermatol
Year:
2022
Journal volume:
142
Journal issue:
1
Pages contribution:
14-15
Fulltext / DOI:
doi:10.1016/j.jid.2021.07.161
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34565563
Print-ISSN:
0022-202X
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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