IFN-1s: Sentinels Shaping Distinct Immune Responses in Skin.

Titel:: IFN-1s: Sentinels Shaping Distinct Immune Responses in Skin.
Dokumenttyp:: Journal Article; Comment
Autor(en):: Garzorz-Stark, Natalie; Eyerich, Kilian
Abstract:: IFN-1s are early sentinels of potential danger in skin. Two interconnected axes exist: plasmacytoid dendritic cells (DCs) secreting IFN-α in response to single strand RNA or DNA and keratinocytes secreting IFN-κ after stimulation with double strand RNA or other IFNs. Both IFN-α and IFN-κ induce macrophages and DC subpopulations to secrete master regulators of cytotoxicity or wound healing, the latter related to psoriasis pathogenesis.
Zeitschriftentitel:: J Invest Dermatol
Jahr:: 2022
Band / Volume:: 142
Heft / Issue:: 1
Seitenangaben Beitrag:: 14-15
Volltext / DOI:: doi:10.1016/j.jid.2021.07.161
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/34565563
Print-ISSN:: 0022-202X
TUM Einrichtung:: Klinik und Poliklinik für Dermatologie und Allergologie
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