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Titel:

Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues.

Dokumenttyp:
Article; Journal Article
Autor(en):
Bartenschlager, Florian; Klymiuk, Nikolai; Weise, Christoph; Kuropka, Benno; Gruber, Achim D; Mundhenk, Lars
Abstract:
Species-specific diversities are particular features of mammalian chloride channel regulator, calcium activated (CLCA) genes. In contrast to four complex gene clusters in mammals, only two CLCA genes appear to exist in chickens. CLCA2 is conserved in both, while only the galline CLCA1 (gCLCA1) displays close genetic distance to mammalian clusters 1, 3 and 4. In this study, sequence analyses and biochemical characterizations revealed that gCLCA1 as a putative avian prototype shares common protein...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2022
Band / Volume:
17
Heft / Issue:
4
Volltext / DOI:
doi:10.1371/journal.pone.0266937
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35417490
Print-ISSN:
1932-6203
TUM Einrichtung:
Professur für Kardiovaskuläre Translation in Großtiermodellen (Prof. Klymiuk)
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