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Titel:

TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium.

Dokumenttyp:
Journal Article
Autor(en):
Fleurot, Isabelle; López-Gálvez, Raquel; Barbry, Pascal; Guillon, Antoine; Si-Tahar, Mustapha; Bähr, Andrea; Klymiuk, Nikolai; Sirard, Jean-Claude; Caballero, Ignacio
Abstract:
Excessive lung inflammation and airway epithelium damage are hallmarks of cystic fibrosis (CF) disease. It is unclear whether lung inflammation is related to an intrinsic defect in the immune response or to chronic infection. We aimed to determine whether TLR5-mediated response is defective in the CF airway epithelium. We used a newborn CF pig model to study intrinsic alterations in CF airway epithelium innate immune response. Airway epithelial cells (AECs) were stimulated with flagellin or lipo...     »
Zeitschriftentitel:
J Cyst Fibros
Jahr:
2022
Band / Volume:
21
Heft / Issue:
2
Seitenangaben Beitrag:
e117-e121
Volltext / DOI:
doi:10.1016/j.jcf.2021.08.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34420900
Print-ISSN:
1569-1993
TUM Einrichtung:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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