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- Original title:
- Structural biology of the human peroxisomal translocation machinery
- Translated title:
- Strukturbiologie der menschlichen peroxisomalen Translokationsmaschinerie
- Author:
- Gaussmann, Stefan Ferdinand Rudolf
- Year:
- 2022
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Natural Sciences
- Advisor:
- Sattler, Michael (Prof. Dr.)
- Referee:
- Sattler, Michael (Prof. Dr.); Lang, Kathrin (Prof. Dr.); Erdmann, Ralf (Prof. Dr.)
- Language:
- en
- Subject group:
- NAT Naturwissenschaften (allgemein)
- Keywords:
- structural-biology, NMR-spectroscopy, peroxisome, PEX
- Translated keywords:
- Strukturbiologie, NMR-Spektroskopie, Peroxisome, PEX
- TUM classification:
- CHE 808; CHE 244
- Abstract:
- Peroxisomes are ubiquitous eukaryotic organelles essential for lipid metabolism and detoxification of reactive oxygen species. NMR-spectroscopy, X-ray crystallography and biophysical techniques are used to characterize protein-protein and protein-membrane interactions of key peroxisomal proteins, the peroxins PEX5, PEX13 and PEX14, and their role in peroxisomal import and biogenesis.
- Translated abstract:
- Peroxisomen sind in eukaryotischen Zellen vorkommende Organellen, welche für den Lipid-Metabolismus und die Entgiftung von reaktiven oxidativen Metaboliten essentiell sind. In dieser Arbeit werden NMR-Spektroskopie, Röntgenstrukturanalyse und biophysikalische Methoden kombiniert um Protein-Protein und Protein-Membran Wechselwirkungen von wichtigen peroxisomalen Proteinen, den Peroxinen PEX5, PEX13 und PEX14, zu charakterisieren und deren Rolle peroxisomalen Import und Biogenese zu untersuchen.
- WWW:
- https://mediatum.ub.tum.de/?id=1663576
- Date of submission:
- 12.07.2022
- Oral examination:
- 18.10.2022
- File size:
- 10070242 bytes
- Pages:
- 181
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20221018-1663576-1-7
- Last change:
- 18.10.2023
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