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- Original title:
- Ausbruch aus der Ebene: Erkundung des Dreidimensionalen chemischen Strukturraums heterocyclischer Ringe - Diastereoselektive Rhodium-katalysierte Hydrierungen
- Translated title:
- Escape from Flatland: Exploring the Three-Dimensional Chemical Structure Space of Heterocyclic Rings - Diastereoselective Rhodium-Catalyzed Hydrogenation Reactions
- Author:
- Schiwek, Christian Herbert
- Year:
- 2022
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Natural Sciences
- Advisor:
- Bach, Thorsten (Prof. Dr.)
- Referee:
- Bach, Thorsten (Prof. Dr.); Köhler, Klaus (Prof. Dr.)
- Language:
- de
- Subject group:
- CHE Chemie
- TUM classification:
- CHE 600
- Abstract:
- Aliphatische N-Heterocyclen, wie Octahydroindolone oder aliphatische 2,5-Diketopiperazine (2,5-DKPs) gehören zu den begehrtesten Gerüsten in Naturstoffen, Pharmazeutika und Agrochemikalien. Wir berichten hier über die neuartige chemo- und diastereoselektive Arenhydrierung einer Reihe von N-Heterocyclen, darunter 2-Oxindole, 3,4-Dihydrochinolone sowie 2,5-DKPs und verwandte Strukturen. Diese Ergebnisse sind weitere Schritte zur Eroberung des dreidimensionalen chemischen Strukturraums.
- Translated abstract:
- Aliphatic N-heterocycles, like octahydroindolones or aliphatic 2,5-diketopiperazines (2,5-DKPs) are among the most coveted scaffolds in natural products, pharmaceuticals and agrochemicals. We herein reported the novel chemo- and diastereoselective arene hydrogenation of an array of N-heterocycles including 2-oxindoles, 3,4-dihydroquinolones as well as 2,5-DKPs and related structures. These advances are further steps to conquer the three dimensional chemical structure space.
- ISBN:
- 978-3-8439-5135-7
- WWW:
- https://mediatum.ub.tum.de/?id=1655346
- Date of submission:
- 13.04.2022
- Oral examination:
- 24.06.2022
- Last change:
- 02.11.2022
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