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Titel:

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Oeckl, Josef; Janovska, Petra; Adamcova, Katerina; Bardova, Kristina; Brunner, Sarah; Dieckmann, Sebastian; Ecker, Josef; Fromme, Tobias; Funda, Jiri; Gantert, Thomas; Giansanti, Piero; Hidrobo, Maria Soledad; Kuda, Ondrej; Kuster, Bernhard; Li, Yongguo; Pohl, Radek; Schmitt, Sabine; Schweizer, Sabine; Zischka, Hans; Zouhar, Petr; Kopecky, Jan; Klingenspor, Martin
Abstract:
Objective: Classical ATP-independent non-shivering thermogenesis enabled by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in the cold. It has long been suspected that futile ATP-consuming substrate cycles also contribute to thermogenesis and can partially compensate for the genetic ablation of UCP1 in mouse models. Futile ATP-dependent thermogenesis could thereby enable survival in the cold even when brown fat is less abundant or missing....     »
Stichworte:
BayBioMS; Brown adipose tissue; Fatty acids; Futile substrate cycle; Lipolysis; Re-esterification; UCP1-independent thermogenesis
Zeitschriftentitel:
Molecular Metabolism
Jahr:
2022
Seitenangaben Beitrag:
101499
Volltext / DOI:
doi:10.1016/j.molmet.2022.101499
Verlag / Institution:
Elsevier BV
E-ISSN:
2212-8778
Publikationsdatum:
01.04.2022
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