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Title:

Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome

Document type:
Zeitschriftenaufsatz
Author(s):
Altaha, Baraa; Heddes, Marjolein; Pilorz, Violetta; Niu, Yunhui; Gorbunova, Elizaveta; Gigl, Michael; Kleigrewe, Karin; Oster, Henrik; Haller, Dirk; Kiessling, Silke
Abstract:
Objective Internal clocks time behavior and physiology, including the gut microbiome, in a circadian (∼24 h) manner. Mismatch between internal and external time, e.g. during shift work, disrupts circadian system coordination promoting the development of obesity and type 2 diabetes (T2D). Conversely, body weight changes induce microbiota dysbiosis. The relationship between circadian disruption and microbiota dysbiosis in metabolic diseases, however, remains largely unknown. Methods Core and...     »
Keywords:
BayBioMS; circadian rhythmSCNshift workmicrobiotashort chain fatty acidsbile acids
Journal title:
Molecular Metabolism
Year:
2022
Pages contribution:
101628
Fulltext / DOI:
doi:10.1016/j.molmet.2022.101628
Publisher:
Elsevier BV
E-ISSN:
2212-8778
Date of publication:
01.11.2022
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