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Title:

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning

Document type:
Zeitschriftenaufsatz
Author(s):
Stepan, Jens; Heinz, Daniel E.; Dethloff, Frederik; Bajaj, Thomas; Zellner, Andreas; Hafner, Kathrin; Wiechmann, Svenja; Mackert, Sarah; Mecdad, Yara; Rabenstein, Michael; Ebert, Tim; Martinelli, Silvia; Häusl, Alexander S.; Pöhlmann, Maximilian L.; Hermann, Anke; Ma, Xiao; Pavenstädt, Hermann; Schmidt, Mathias V.; Philipsen, Alexandra; Turck, Chris W.; Deussing, Jan M.; Kuster, Bernhard; Wehr, Michael C.; Stein, Valentin; Kremerskothen, Joachim; Wotjak, Carsten T.; Gassen, Nils C.
Abstract:
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing protein 1 (WWC1) regulates AMPAR surface expression and impacts on memory performance. However, synaptic binding partners of WWC1 and its hierarchical position in AMPAR complexes are largely unclear. Using cell-surface proteomics in hippocampal tissue of...     »
Keywords:
BayBioMS; AMPA receptor; CP: Neuroscience; Hippo pathway; KIBRA; LATS; WWC1; hippocampus; learning and memory; pro-cognitive; synapse; synaptic proteomics.
Journal title:
Cell Reports
Year:
2022
Journal volume:
41
Journal issue:
10
Pages contribution:
111766
Fulltext / DOI:
doi:10.1016/j.celrep.2022.111766
Publisher:
Elsevier BV
E-ISSN:
2211-1247
Date of publication:
01.12.2022
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