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Titel:

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schick, Markus; Zhang, Le; Maurer, Sabine; Maurer, Hans Carlo; Isaakaidis, Konstandina; Schneider, Lara; Patra, Upayan; Schunck, Kathrin; Rohleder, Elena; Hofstetter, Julia; Baluapuri, Apoorva; Scherger, Anna Katharina; Slotta-Huspenina, Julia; Hettler, Franziska; Weber, Julia; Engleitner, Thomas; Maresch, Roman; Slawska, Jolanta; Lewis, Richard; Istvanffy, Rouzanna; Habringer, Stefan; Steiger, Katja; Baiker, Armin; Oostendorp, Robert A J; Miething, Cornelius; Lenhof, Hans-Peter; Bassermann, Flo...     »
Abstract:
SUMOylation is a post-translational modification of proteins that regulates these proteins' localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide transposon mutagenesis screen in a MYC-driven B-cell lymphoma model, we here identify the SUMO isopeptidase (or deconjugase) SENP6 as a tumor suppressor that links unrestricted SUMOylation to tumor development and progression. Notably, SENP6 is recurrently deleted in...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2022
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-021-27704-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35022408
Print-ISSN:
2041-1723
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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