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Title:

Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infection.

Document type:
Journal Article
Author(s):
Wagner, Karolin I; Mateyka, Laura M; Jarosch, Sebastian; Grass, Vincent; Weber, Simone; Schober, Kilian; Hammel, Monika; Burrell, Teresa; Kalali, Behnam; Poppert, Holger; Beyer, Henriette; Schambeck, Sophia; Holdenrieder, Stefan; Strötges-Achatz, Andrea; Haselmann, Verena; Neumaier, Michael; Erber, Johanna; Priller, Alina; Yazici, Sarah; Roggendorf, Hedwig; Odendahl, Marcus; Tonn, Torsten; Dick, Andrea; Witter, Klaus; Mijočević, Hrvoje; Protzer, Ulrike; Knolle, Percy A; Pichlmair, Andreas; Crowe...     »
Abstract:
T cell immunity is crucial for control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been studied widely on a quantitative level. However, the quality of responses, in particular of CD8+ T cells, has only been investigated marginally so far. Here, we isolate T cell receptor (TCR) repertoires specific for immunodominant SARS-CoV-2 epitopes restricted to common human Leukocyte antigen (HLA) class I molecules in convalescent individuals. SARS-CoV-2-specific CD8+...     »
Journal title abbreviation:
Cell Rep
Year:
2022
Journal volume:
38
Journal issue:
2
Fulltext / DOI:
doi:10.1016/j.celrep.2021.110214
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34968416
Print-ISSN:
2211-1247
TUM Institution:
Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Institut für Virologie (Prof. Protzer); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Roman Herzog Comprehensive Cancer Center
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