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Titel:

The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.

Dokumenttyp:
Journal Article
Autor(en):
Bulthuis, Elianne P; Einer, Claudia; Distelmaier, Felix; Groh, Laszlo; van Emst-de Vries, Sjenet E; van de Westerlo, Els; van de Wal, Melissa; Wagenaars, Jori; Rodenburg, Richard J; Smeitink, Jan A M; Riksen, Niels P; Willems, Peter H G M; Adjobo-Hermans, Merel J W; Zischka, Hans; Koopman, Werner J H
Abstract:
Attachment of cargo molecules to lipophilic triphenylphosphonium (TPP+) cations is a widely applied strategy for mitochondrial targeting. We previously demonstrated that the vitamin E-derived antioxidant Trolox increases the levels of active mitochondrial complex I (CI), the first complex of the electron transport chain (ETC), in primary human skin fibroblasts (PHSFs) of Leigh Syndrome (LS) patients with isolated CI deficiency. Primed by this finding, we here studied the cellular effects of mito...     »
Zeitschriftentitel:
Free Radic Biol Med
Jahr:
2022
Band / Volume:
188
Seitenangaben Beitrag:
434-446
Volltext / DOI:
doi:10.1016/j.freeradbiomed.2022.06.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35718301
Print-ISSN:
0891-5849
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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