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Title:

The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.

Document type:
Journal Article
Author(s):
Bulthuis, Elianne P; Einer, Claudia; Distelmaier, Felix; Groh, Laszlo; van Emst-de Vries, Sjenet E; van de Westerlo, Els; van de Wal, Melissa; Wagenaars, Jori; Rodenburg, Richard J; Smeitink, Jan A M; Riksen, Niels P; Willems, Peter H G M; Adjobo-Hermans, Merel J W; Zischka, Hans; Koopman, Werner J H
Abstract:
Attachment of cargo molecules to lipophilic triphenylphosphonium (TPP+) cations is a widely applied strategy for mitochondrial targeting. We previously demonstrated that the vitamin E-derived antioxidant Trolox increases the levels of active mitochondrial complex I (CI), the first complex of the electron transport chain (ETC), in primary human skin fibroblasts (PHSFs) of Leigh Syndrome (LS) patients with isolated CI deficiency. Primed by this finding, we here studied the cellular effects of mito...     »
Journal title abbreviation:
Free Radic Biol Med
Year:
2022
Journal volume:
188
Pages contribution:
434-446
Fulltext / DOI:
doi:10.1016/j.freeradbiomed.2022.06.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35718301
Print-ISSN:
0891-5849
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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