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Title:

Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Möhrmann, Lino; Werner, Maximilian; Oleś, Małgorzata; Mock, Andreas; Uhrig, Sebastian; Jahn, Arne; Kreutzfeldt, Simon; Fröhlich, Martina; Hutter, Barbara; Paramasivam, Nagarajan; Richter, Daniela; Beck, Katja; Winter, Ulrike; Pfütze, Katrin; Heilig, Christoph E; Teleanu, Veronica; Lipka, Daniel B; Zapatka, Marc; Hanf, Dorothea; List, Catrin; Allgäuer, Michael; Penzel, Roland; Rüter, Gina; Jelas, Ivan; Hamacher, Rainer; Falkenhorst, Johanna; Wagner, Sebastian; Brandts, Christian H; Boerries, Mela...     »
Abstract:
The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is unclear. Here, we use comprehensive molecular characterization by whole genome/exome, transcriptome and methylome analysis in 70 CUP patients to reveal substantial mutational heterogeneity with TP53, MUC16, KRAS, LRP1B and CSMD3 being the most frequently mutated known cancer-related genes. The most common fusion partner is FGFR2, the most common focal homozygous deletion affects CDKN2A. 56/70 (80%) patients recei...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-022-31866-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35918329
Print-ISSN:
2041-1723
TUM Institution:
608; Institut für Allgemeine Pathologie und Pathologische Anatomie
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