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Title:

In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity.

Document type:
Journal Article
Author(s):
Manske, Katrin; Schneider, Annika; Ko, Chunkyu; Knolle, Percy A; Steiger, Katja; Protzer, Ulrike; Wohlleber, Dirk
Abstract:
Immunity against hepatitis B virus (HBV) infection is complex and not entirely understood so far, including the decisive factors leading to the development of chronic hepatitis B. This lack of a mechanistic understanding of HBV-specific immunity is also caused by a limited number of suitable animal models. Here, we describe the generation of a recombinant adenovirus expressing an HBV 1.3-overlength genome linked to luciferase (Ad-HBV-Luc) allowing for precise analysis of the quantity of infected...     »
Journal title abbreviation:
Viruses
Year:
2021
Journal volume:
13
Journal issue:
11
Fulltext / DOI:
doi:10.3390/v13112273
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34835079
Print-ISSN:
1999-4915
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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