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Document type:
Journal Article; Review
Author(s):
Steiger, Katja; Quigley, Neil Gerard; Groll, Tanja; Richter, Frauke; Zierke, Maximilian Alexander; Beer, Ambros Johannes; Weichert, Wilko; Schwaiger, Markus; Kossatz, Susanne; Notni, Johannes
Title:
There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography.
Abstract:
BACKGROUND: In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there are no less than 24 known integrins, and peptides without the RGD sequence as well as non-peptidic ligands play an equally important role as selective integrin ligands. On the other hand, multimerization is a well-established method to increase the avidity of binding structures,...     »
Journal title abbreviation:
EJNMMI Res
Year:
2021
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13550-021-00842-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34636990
Print-ISSN:
2191-219X
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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