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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Renner, Simone; Martins, Ana Sofia; Streckel, Elisabeth; Braun-Reichhart, Christina; Backman, Mattias; Prehn, Cornelia; Klymiuk, Nikolai; Bähr, Andrea; Blutke, Andreas; Landbrecht-Schessl, Christina; Wünsch, Annegret; Kessler, Barbara; Kurome, Mayuko; Hinrichs, Arne; Koopmans, Sietse-Jan; Krebs, Stefan; Kemter, Elisabeth; Rathkolb, Birgit; Nagashima, Hiroshi; Blum, Helmut; Ritzmann, Mathias; Wanke, Rüdiger; Aigner, Bernhard; Adamski, Jerzy; Hrabě de Angelis, Martin; Wolf, Eckhard
Title:
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.
Abstract:
Alongside the obesity epidemic, the prevalence of maternal diabetes is rising worldwide, and adverse effects on fetal development and metabolic disturbances in the offspring's later life have been described. To clarify whether metabolic programming effects are due to mild maternal hyperglycemia without confounding obesity, we investigated wild-type offspring of INSC93S transgenic pigs, which are a novel genetically modified large-animal model expressing mutant insulin (INS) C93S in pancreatic β-...     »
Journal title abbreviation:
Dis Model Mech
Year:
2019
Journal volume:
12
Journal issue:
8
Fulltext / DOI:
doi:10.1242/dmm.039156
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31308048
Print-ISSN:
1754-8403
TUM Institution:
1693; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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