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Title:

Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Liu, Peter Jianrui; Harris, James M; Marchi, Emanuele; D'Arienzo, Valentina; Michler, Thomas; Wing, Peter A C; Magri, Andrea; Ortega-Prieto, Ana Maria; van de Klundert, Maarten; Wettengel, Jochen; Durantel, David; Dorner, Marcus; Klenerman, Paul; Protzer, Ulrike; Giotis, Efstathios S; McKeating, Jane A
Abstract:
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently perturbed by pathological states including infection and inflammation. We discovered a significant upregulation of hypoxia regulated gene transcripts in patients with chronic hepatitis B (CHB) in the absence of liver cirrhosis. We used state-of-the-art in vitro and in vivo H...     »
Journal title abbreviation:
Sci Rep
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-70865-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32839523
Print-ISSN:
2045-2322
TUM Institution:
Institut für Virologie
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