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Title:

Analysis pipelines for cancer genome sequencing in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lange, Sebastian; Engleitner, Thomas; Mueller, Sebastian; Maresch, Roman; Zwiebel, Maximilian; González-Silva, Laura; Schneider, Günter; Banerjee, Ruby; Yang, Fengtang; Vassiliou, George S; Friedrich, Mathias J; Saur, Dieter; Varela, Ignacio; Rad, Roland
Abstract:
Mouse models of human cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes. Both reverse and forward genetics in mice are currently gaining momentum through advances in next-generation sequencing (NGS). Methodologies to analyze sequencing data were, however, developed for humans and hence do not account for species-specific differences in genome structures and experimental setups. Here, we describe standardized computational pipelines specifically tailored to...     »
Journal title abbreviation:
Nat Protoc
Year:
2020
Journal volume:
15
Journal issue:
2
Pages contribution:
266-315
Fulltext / DOI:
doi:10.1038/s41596-019-0234-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31907453
Print-ISSN:
1754-2189
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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