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Title:

c-Rel gain in B cells drives germinal center reactions and autoantibody production.

Document type:
Journal Article
Author(s):
Kober-Hasslacher, Maike; Oh-Strauß, Hyunju; Kumar, Dilip; Soberón, Valeria; Diehl, Carina; Lech, Maciej; Engleitner, Thomas; Katab, Eslam; Fernandez Saiz, Vanesa; Piontek, Guido; Li, Hongwei; Menze, Björn; Ziegenhain, Christoph; Enard, Wolfgang; Rad, Roland; Böttcher, Jan P; Anders, Hans-Joachim; Rudelius, Martina; Schmidt-Supprian, Marc
Abstract:
Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B cells from BAC-transgenic gene loci and demonstrate that c-Rel protein levels linearly dictated expansion of germinal center B (GCB) cells and isotype-switched plasma cells. c-Rel expression in B cells of...     »
Journal title abbreviation:
J Clin Invest
Year:
2020
Journal volume:
130
Journal issue:
6
Pages contribution:
3270-3286
Fulltext / DOI:
doi:10.1172/JCI124382
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32191641
Print-ISSN:
0021-9738
TUM Institution:
602; Experimentelle Hämatologie (Prof. Schmidt-Supprian); Fachgebiet Nephrologie (Prof. Heemann); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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