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Titel:

Analysis pipelines for cancer genome sequencing in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lange, Sebastian; Engleitner, Thomas; Mueller, Sebastian; Maresch, Roman; Zwiebel, Maximilian; González-Silva, Laura; Schneider, Günter; Banerjee, Ruby; Yang, Fengtang; Vassiliou, George S; Friedrich, Mathias J; Saur, Dieter; Varela, Ignacio; Rad, Roland
Abstract:
Mouse models of human cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes. Both reverse and forward genetics in mice are currently gaining momentum through advances in next-generation sequencing (NGS). Methodologies to analyze sequencing data were, however, developed for humans and hence do not account for species-specific differences in genome structures and experimental setups. Here, we describe standardized computational pipelines specifically tailored to...     »
Zeitschriftentitel:
Nat Protoc
Jahr:
2020
Band / Volume:
15
Heft / Issue:
2
Seitenangaben Beitrag:
266-315
Volltext / DOI:
doi:10.1038/s41596-019-0234-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31907453
Print-ISSN:
1754-2189
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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