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Title:

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Berghoff, Stefan A; Spieth, Lena; Sun, Ting; Hosang, Leon; Schlaphoff, Lennart; Depp, Constanze; Düking, Tim; Winchenbach, Jan; Neuber, Jonathan; Ewers, David; Scholz, Patricia; van der Meer, Franziska; Cantuti-Castelvetri, Ludovico; Sasmita, Andrew O; Meschkat, Martin; Ruhwedel, Torben; Möbius, Wiebke; Sankowski, Roman; Prinz, Marco; Huitinga, Inge; Sereda, Michael W; Odoardi, Francesca; Ischebeck, Till; Simons, Mikael; Stadelmann-Nessler, Christine; Edgar, Julia M; Nave, Klaus-Armin; Saher, Ge...     »
Abstract:
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subsequently, oligodendrocytes increase cholesterol levels as a prerequisite for synthesizing new myelin membranes. We hypothesized that lesion resolution is regulated by the fate of cholesterol from damaged myelin and oligodendroglial sterol synthesis. By...     »
Journal title abbreviation:
Nat Neurosci
Year:
2021
Journal volume:
24
Journal issue:
1
Pages contribution:
47-60
Fulltext / DOI:
doi:10.1038/s41593-020-00757-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33349711
Print-ISSN:
1097-6256
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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