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Titel:

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Jafari, Mehrnoosh; Schumacher, Adrian-Minh; Snaidero, Nicolas; Ullrich Gavilanes, Emily M; Neziraj, Tradite; Kocsis-Jutka, Virág; Engels, Daniel; Jürgens, Tanja; Wagner, Ingrid; Weidinger, Juan Daniel Flórez; Schmidt, Stephanie S; Beltrán, Eduardo; Hagan, Nellwyn; Woodworth, Lisa; Ofengeim, Dimitry; Gans, Joseph; Wolf, Fred; Kreutzfeldt, Mario; Portugues, Ruben; Merkler, Doron; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. In the present study, we use functional and structural in vivo imaging in a mouse model of cortical MS to demonstrate that bouts of cortical inflammation disrupt cortical circuit activity coincident with a widespread, but transient, loss of dendritic spines...     »
Zeitschriftentitel:
Nat Neurosci
Jahr:
2021
Band / Volume:
24
Heft / Issue:
3
Seitenangaben Beitrag:
355-367
Volltext / DOI:
doi:10.1038/s41593-020-00780-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33495636
Print-ISSN:
1097-6256
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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