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Titel:

TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kälin, Roland E; Cai, Linzhi; Li, Yuping; Zhao, Dongxu; Zhang, Huabin; Cheng, Jiying; Zhang, Wenlong; Wu, Yingxi; Eisenhut, Katharina; Janssen, Philipp; Schmitt, Lukas; Enard, Wolfgang; Michels, Friederike; Flüh, Charlotte; Hou, Mengzhuo; Kirchleitner, Sabrina V; Siller, Sebastian; Schiemann, Matthias; Andrä, Immanuel; Montanez, Eloi; Giachino, Claudio; Taylor, Verdon; Synowitz, Michael; Tonn, Jörg-Christian; von Baumgarten, Louisa; Schulz, Christian; Hellmann, Ines; Glass, Rainer
Abstract:
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP)...     »
Zeitschriftentitel:
Cell Syst
Jahr:
2021
Band / Volume:
12
Heft / Issue:
3
Seitenangaben Beitrag:
248-262.e7
Volltext / DOI:
doi:10.1016/j.cels.2021.01.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33592194
Print-ISSN:
2405-4712
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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