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Title:

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Mathewson, Nathan D; Ashenberg, Orr; Tirosh, Itay; Gritsch, Simon; Perez, Elizabeth M; Marx, Sascha; Jerby-Arnon, Livnat; Chanoch-Myers, Rony; Hara, Toshiro; Richman, Alyssa R; Ito, Yoshinaga; Pyrdol, Jason; Friedrich, Mirco; Schumann, Kathrin; Poitras, Michael J; Gokhale, Prafulla C; Gonzalez Castro, L Nicolas; Shore, Marni E; Hebert, Christine M; Shaw, Brian; Cahill, Heather L; Drummond, Matthew; Zhang, Wubing; Olawoyin, Olamide; Wakimoto, Hiroaki; Rozenblatt-Rosen, Orit; Brastianos, Priscilla...     »
Abstract:
T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-seq) to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma. We identify potential effectors of anti-tumor immunity in subsets of T cells that co-express cytotoxic programs and several natur...     »
Journal title abbreviation:
Cell
Year:
2021
Journal volume:
184
Journal issue:
5
Pages contribution:
1281-1298.e26
Fulltext / DOI:
doi:10.1016/j.cell.2021.01.022
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33592174
Print-ISSN:
0092-8674
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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