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Titel:

Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer.

Dokumenttyp:
Journal Article
Autor(en):
Li, Xue; Zheng, Nai-Ren; Wang, Lin-Heng; Li, Zhong-Wu; Liu, Zong-Chao; Fan, Hua; Wang, Yi; Dai, Jin; Ni, Xiao-Tian; Wei, Xin; Liu, Ming-Wei; Li, Kai; Li, Zhe-Xuan; Zhou, Tong; Zhang, Yang; Zhang, Jing-Ying; Kadeerhan, Gaohaer; Huang, Sha; Wu, Wen-Hui; Liu, Wei-Dong; Wu, Xiu-Zhen; Zhang, Lan-Fu; Xu, Jian-Ming; Gerhard, Markus; You, Wei-Cheng; Pan, Kai-Feng; Li, Wen-Qing; Qin, Jun
Abstract:
BACKGROUND: Molecular features underlining the multistage progression of gastric lesions and development of early gastric cancer (GC) are poorly understood, restricting the ability to GC prevention and management. METHODS: We portrayed proteomic landscape and explored proteomic signatures associated with progression of gastric lesions and risk of early GC. Tissue proteomic profiling was conducted for a total of 324 subjects. A case-control study was performed in the discovery stage (n=169) based...     »
Zeitschriftentitel:
EBioMedicine
Jahr:
2021
Band / Volume:
74
Volltext / DOI:
doi:10.1016/j.ebiom.2021.103714
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34818622
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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