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Title:

Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development.

Document type:
Zeitschriftenaufsatz
Author(s):
Mohr, Hermine; Ballke, Simone; Bechmann, Nicole; Gulde, Sebastian; Malekzadeh-Najafabadi, Jaber; Peitzsch, Mirko; Ntziachristos, Vasilis; Steiger, Katja; Wiedemann, Tobias; Pellegata, Natalia S
Abstract:
BACKGROUND: Pseudohypoxic tumors activate pro-oncogenic pathways typically associated with severe hypoxia even when sufficient oxygen is present, leading to highly aggressive tumors. Prime examples are pseudohypoxic pheochromocytomas and paragangliomas (p-PPGLs), neuroendendocrine tumors currently lacking effective therapy. Previous attempts to generate mouse models for p-PPGLs all failed. Here, we describe that the rat MENX line, carrying a Cdkn1b (p27) frameshift-mutation, spontaneously develo...     »
Journal title:
Cancers
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.3390/cancers13010126
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33401758
WWW:
https://www.mdpi.com/2072-6694/13/1/126
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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