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Title:

Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tian, Weili; Czopka, Tim; López-Schier, Hernán
Abstract:
Protecting the nervous system from chronic effects of physical and chemical stress is a pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Thus, blocking Sarm1 function is emerging as a promising neuroprotective strategy with therapeutic relevance. Yet, the conditions that will most benefit from inhibiting Sarm1 remain undefined. Here we combine genome engineering, pharmacology and high-resolution intravital videmicroscopy in ze...     »
Journal title abbreviation:
Commun Biol
Year:
2020
Journal volume:
3
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s42003-020-0776-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32001778
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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