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Title:

Kill one or kill the many: interplay between mitophagy and apoptosis.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Wanderoy, Simone; Hees, J Tabitha; Klesse, Ramona; Edlich, Frank; Harbauer, Angelika B
Abstract:
Mitochondria are key players of cellular metabolism, Ca2+ homeostasis, and apoptosis. The functionality of mitochondria is tightly regulated, and dysfunctional mitochondria are removed via mitophagy, a specialized form of autophagy that is compromised in hereditary forms of Parkinson's disease. Through mitophagy, cells are able to cope with mitochondrial stress until the damage becomes too great, which leads to the activation of pro-apoptotic BCL-2 family proteins located on the outer mitochondr...     »
Journal title abbreviation:
Biol Chem
Year:
2020
Journal volume:
402
Journal issue:
1
Pages contribution:
73-88
Fulltext / DOI:
doi:10.1515/hsz-2020-0231
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33544491
Print-ISSN:
1431-6730
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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