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Titel:

Kill one or kill the many: interplay between mitophagy and apoptosis.

Dokumenttyp:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Wanderoy, Simone; Hees, J Tabitha; Klesse, Ramona; Edlich, Frank; Harbauer, Angelika B
Abstract:
Mitochondria are key players of cellular metabolism, Ca2+ homeostasis, and apoptosis. The functionality of mitochondria is tightly regulated, and dysfunctional mitochondria are removed via mitophagy, a specialized form of autophagy that is compromised in hereditary forms of Parkinson's disease. Through mitophagy, cells are able to cope with mitochondrial stress until the damage becomes too great, which leads to the activation of pro-apoptotic BCL-2 family proteins located on the outer mitochondr...     »
Zeitschriftentitel:
Biol Chem
Jahr:
2020
Band / Volume:
402
Heft / Issue:
1
Seitenangaben Beitrag:
73-88
Volltext / DOI:
doi:10.1515/hsz-2020-0231
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33544491
Print-ISSN:
1431-6730
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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