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Titel:

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.

Dokumenttyp:
Article; Journal Article
Autor(en):
Mukherjee, Chaitali; Kling, Tina; Russo, Belisa; Miebach, Kerstin; Kess, Eva; Schifferer, Martina; Pedro, Liliana D; Weikert, Ulrich; Fard, Maryam K; Kannaiyan, Nirmal; Rossner, Moritz; Aicher, Marie-Louise; Goebbels, Sandra; Nave, Klaus-Armin; Krämer-Albers, Eva-Maria; Schneider, Anja; Simons, Mikael
Abstract:
An evolutionarily conserved function of glia is to provide metabolic and structural support for neurons. To identify molecules generated by glia and with vital functions for neurons, we used Drosophila melanogaster as a screening tool, and subsequently translated the findings to mice. We found that a cargo receptor operating in the secretory pathway of glia was essential to maintain axonal integrity by regulating iron buffering. Ferritin heavy chain was identified as the critical secretory cargo...     »
Zeitschriftentitel:
Cell Metab
Jahr:
2020
Band / Volume:
32
Heft / Issue:
2
Seitenangaben Beitrag:
259-272.e10
Volltext / DOI:
doi:10.1016/j.cmet.2020.05.019
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32531201
Print-ISSN:
1550-4131
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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