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Title:

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy.

Document type:
Journal Article
Author(s):
Viereck, Janika; Bührke, Anne; Foinquinos, Ariana; Chatterjee, Shambhabi; Kleeberger, Jan A; Xiao, Ke; Janssen-Peters, Heike; Batkai, Sandor; Ramanujam, Deepak; Kraft, Theresia; Cebotari, Serghei; Gueler, Faikah; Beyer, Andreas M; Schmitz, Jessica; Bräsen, Jan H; Schmitto, Jan D; Gyöngyösi, Mariann; Löser, Alexandra; Hirt, Marc N; Eschenhagen, Thomas; Engelhardt, Stefan; Bär, Christian; Thum, Thomas
Abstract:
AIMS: Pathological cardiac remodelling and subsequent heart failure represents an unmet clinical need. Long non-coding RNAs (lncRNAs) are emerging as crucial molecular orchestrators of disease processes, including that of heart diseases. Here, we report on the powerful therapeutic potential of the conserved lncRNA H19 in the treatment of pathological cardiac hypertrophy. METHOD AND RESULTS: Pressure overload-induced left ventricular cardiac remodelling revealed an up-regulation of H19 in the ear...     »
Journal title abbreviation:
Eur Heart J
Year:
2020
Journal volume:
41
Journal issue:
36
Pages contribution:
3462-3474
Fulltext / DOI:
doi:10.1093/eurheartj/ehaa519
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32657324
Print-ISSN:
0195-668X
TUM Institution:
Institut für Pharmakologie und Toxikologie
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