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Title:

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Trembinski, D Julia; Bink, Diewertje I; Theodorou, Kosta; Sommer, Janina; Fischer, Ariane; van Bergen, Anke; Kuo, Chao-Chung; Costa, Ivan G; Schürmann, Christoph; Leisegang, Matthias S; Brandes, Ralf P; Alekseeva, Tijna; Brill, Boris; Wietelmann, Astrid; Johnson, Christopher N; Spring-Connell, Alexander; Kaulich, Manuel; Werfel, Stanislas; Engelhardt, Stefan; Hirt, Marc N; Yorgan, Kaja; Eschenhagen, Thomas; Kirchhof, Luisa; Hofmann, Patrick; Jaé, Nicolas; Wittig, Ilka; Hamdani, Nazha; Bischof, C...     »
Abstract:
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregul...     »
Journal title abbreviation:
Nat Commun
Year:
2020
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-020-15995-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32341350
Print-ISSN:
2041-1723
TUM Institution:
Institut für Pharmakologie und Toxikologie
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