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Title:

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Weinberger, Tobias; Esfandyari, Dena; Messerer, Denise; Percin, Gulce; Schleifer, Christian; Thaler, Raffael; Liu, Lulu; Stremmel, Christopher; Schneider, Vanessa; Vagnozzi, Ronald J; Schwanenkamp, Jennifer; Fischer, Maximilian; Busch, Katrin; Klapproth, Kay; Ishikawa-Ankerhold, Hellen; Klösges, Lukas; Titova, Anna; Molkentin, Jeffery D; Kobayashi, Yasuhiro; Engelhardt, Stefan; Massberg, Steffen; Waskow, Claudia; Perdiguero, Elisa Gomez; Schulz, Christian
Abstract:
Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation. Yolk sac erythro-myeloid progenitors (EMP) contribute substantially to adventitial macrophages and give rise to a defin...     »
Journal title abbreviation:
Nat Commun
Year:
2020
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-020-18287-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32917889
Print-ISSN:
2041-1723
TUM Institution:
Institut für Pharmakologie und Toxikologie
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