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Title:

MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schober, Sebastian J; Thiede, Melanie; Gassmann, Hendrik; Prexler, Carolin; Xue, Busheng; Schirmer, David; Wohlleber, Dirk; Stein, Stefanie; Grünewald, Thomas G P; Busch, Dirk H; Richter, Guenther H S; Burdach, Stefan E G; Thiel, Uwe
Abstract:
In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated antigen, which is overexpressed in many cancers, including Ewing sarcoma (EwS). Based on previous observations, we postulated strong antitumor potential of tumor-redirected CD4+ T ce...     »
Journal title abbreviation:
Cells
Year:
2020
Journal volume:
9
Journal issue:
7
Fulltext / DOI:
doi:10.3390/cells9071581
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32610710
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin; Roman Herzog Comprehensive Cancer Center
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