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Title:

Notch2-mediated plasticity between marginal zone and follicular B cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lechner, Markus; Engleitner, Thomas; Babushku, Tea; Schmidt-Supprian, Marc; Rad, Roland; Strobl, Lothar J; Zimber-Strobl, Ursula
Abstract:
Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate decision after splenic influx of immature transitional B cells. In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal....     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-21359-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33597542
Print-ISSN:
2041-1723
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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