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Title:

Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.

Document type:
Article; Early Access; Journal Article
Author(s):
Baumann, Peter; Schriever, Sonja C; Kullmann, Stephanie; Zimprich, Annemarie; Peter, Andreas; Gailus-Durner, Valerie; Fuchs, Helmut; Hrabe de Angelis, Martin; Wurst, Wolfgang; Tschöp, Matthias H; Heni, Martin; Hölter, Sabine M; Pfluger, Paul T
Abstract:
BACKGROUND: Dusp8 is the first GWAS-identified gene that is predominantly expressed in the brain and has previously been linked with the development of diabetes type 2 in humans. In this study, we unravel how Dusp8 is involved in the regulation of sucrose reward behavior. METHODS: Female, chow-fed global Dusp8 WT and KO mice were tested in an observer-independent IntelliCage setup for self-administrative sucrose consumption and preference followed by a progressive ratio task with restricted sucr...     »
Journal title abbreviation:
Brain Behav
Year:
2021
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1002/brb3.1928
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33131190
Print-ISSN:
2162-3279
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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