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Title:

Stroma composition and proliferative activity are related to therapy response in neoadjuvant treated pancreatic ductal adenocarcinoma.

Document type:
Journal Article
Author(s):
Haeberle, Lena; Insilla, Andrea Cacciato; Kapp, Anne-Christine; Steiger, Katja; Schlitter, Anna Melissa; Konukiewitz, Björn; Demir, Ihsan Ekin; Friess, Helmut; Esposito, Irene
Abstract:
BACKGROUND: Tumor regression grading (TRG) based on histopathology is the main tool to assess therapy effects after neoadjuvant therapy (NAT) of pancreatic ductal adenocarcinoma (PDAC). However, reliable markers to distinguish therapy effects from pre-existing tumor features are lacking. The aim of this study was the characterization of PDAC after NAT, focusing on the stroma. MATERIAL AND METHODS: Tissue samples from patients resected for PDAC after NAT (n=27) were analyzed. TRG was assessed usi...     »
Journal title abbreviation:
Histol Histopathol
Year:
2021
Journal volume:
36
Journal issue:
7
Pages contribution:
733-742
Fulltext / DOI:
doi:10.14670/HH-18-332
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33769550
Print-ISSN:
0213-3911
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Chirurgie
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