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Titel:

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lankes, Katharina; Hassan, Zonera; Doffo, María Josefina; Schneeweis, Christian; Lier, Svenja; Öllinger, Rupert; Rad, Roland; Krämer, Oliver H; Keller, Ulrich; Saur, Dieter; Reichert, Maximilian; Schneider, Günter; Wirth, Matthias
Abstract:
The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC-active PDAC may lead to novel precise therapies. First, to identify networks with hyperactive MYC, we profiled transcriptomes of established human cell lines, murine primary PDAC cell lines, and accessed publicly available repositories to analyze transcripto...     »
Zeitschriftentitel:
Mol Oncol
Jahr:
2020
Band / Volume:
14
Heft / Issue:
12
Seitenangaben Beitrag:
3048-3064
Volltext / DOI:
doi:10.1002/1878-0261.12835
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33099868
Print-ISSN:
1574-7891
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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