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- Title:
Evaluation of Pre-operative Biopsy, Surgical Procedures and Oncologic Outcomes in Upper Tract Urothelial Carcinoma (UTUC).
- Document type:
- Journal Article
- Author(s):
- Koll, Florestan J; Meisenzahl, Eva; Haller, Bernhard; Maisch, Philipp; Kirchhoff, Florian; Horn, Thomas; Gschwend, Jürgen E; Schmid, Sebastian C
- Abstract:
- Purpose: Discordance between pre-operative biopsy and final pathology for Upper Tract Urothelial Carcinoma (UTUC) is high and optimal management remains controversial. The aim of this study is to evaluate the accuracy of pre-operative biopsy, to identify prognostic factors and to evaluate the effect of adjuvant chemotherapy on survival and oncologic outcome in UTUC. Methods: We analyzed records of patients receiving surgical treatment for UTUC. Pathology of pre-operative biopsy was compared to surgical specimen. We used Kaplan-Meier method to estimate survival probabilities and Cox's proportional hazards models to estimate the association between covariates and event times. Primary endpoint was overall survival (OS). A matched-pair analysis was performed to evaluate the effect of adjuvant chemotherapy. Results: 151 patients underwent surgical treatment (28% open, 36% laparoscopic, 17% robotic radical nephroureterectomy; 14% segmental ureteral resections and 5% palliative nephrectomy) for UTUC and were included in the analysis. Upstaging from
- Journal title abbreviation:
- Front Surg
- Year:
- 2021
- Journal volume:
- 8
- Fulltext / DOI:
- doi:10.3389/fsurg.2021.790738
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/34901146
- TUM Institution:
- Urologische Klinik und Poliklinik
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