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Titel:

A PCR assay to quantify patterns of HBV transcription.

Dokumenttyp:
Journal Article
Autor(en):
D'Arienzo, Valentina; Magri, Andrea; Harris, James M; Wing, Peter A C; Ko, Chunkyu; Rubio, Claudia Orbegozo; Revill, Peter A; Protzer, Ulrike; Balfe, Peter; McKeating, Jane A
Abstract:
Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae and replicates via episomal copies of a covalently closed circular DNA (cccDNA) genome of approximately 3.2 kb. The chromatinization of this small viral genome, with overlapping open reading frames and regulatory elements, suggests an important role for epigenetic pathways to regulate HBV transcription. However, the host pathways that regulate HBV transcription and the temporal nature of promoter usage in infected cells...     »
Zeitschriftentitel:
J Gen Virol
Jahr:
2021
Band / Volume:
102
Heft / Issue:
3
Volltext / DOI:
doi:10.1099/jgv.0.001373
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31846416
Print-ISSN:
0022-1317
TUM Einrichtung:
Institut für Virologie
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