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Title:

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhao, Lili; Chen, Fuwang; Quitt, Oliver; Festag, Marvin; Ringelhan, Marc; Wisskirchen, Karin; Festag, Julia; Yakovleva, Luidmila; Sureau, Camille; Bohne, Felix; Aichler, Michaela; Bruss, Volker; Shevtsov, Maxim; van de Klundert, Maarten; Momburg, Frank; Möhl, Britta S; Protzer, Ulrike
Abstract:
Hepatitis B virus (HBV) infection is a major health threat causing 880,000 deaths each year. Available therapies control viral replication but do not cure HBV, leaving patients at risk to develop hepatocellular carcinoma. Here, we show that HBV envelope proteins (HBs)-besides their integration into endosomal membranes-become embedded in the plasma membrane where they can be targeted by redirected T-cells. HBs was detected on the surface of HBV-infected cells, in livers of mice replicating HBV an...     »
Journal title abbreviation:
Cell Microbiol
Year:
2021
Journal volume:
23
Journal issue:
12
Fulltext / DOI:
doi:10.1111/cmi.13399
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34729894
Print-ISSN:
1462-5814
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie
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